“…the available evidence indicates that antipsychotics aren’t very effective at treating “resistant” depression and aren’t the best choice for this use for most people. …And it remains unclear whether antipsychotics are any better than a placebo at preventing a relapse or return of depression over the long-term. Antipsychotics can also cause serious side effects, such as involuntary movements of the tongue, lips, face, trunk, arms, or legs (tardive dyskinesia), significant weight gain, and an increased risk of type 2 diabetes, heart disease, and stroke. In addition, they are very expensive, with some costing more than $1,000 a month.”
Mysteriously missing from the list of non-medication options is… exercise!